Further Studies on the Role of Metabolites in (±)-3,4-Methylenedioxymethamphetamine-Induced Serotonergic Neurotoxicity
نویسندگان
چکیده
منابع مشابه
Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity.
The mechanism by which the recreational drug (+/-)-3,4-methylenedioxymethamphetamine (MDMA) destroys brain serotonin (5-HT) axon terminals is not understood. Recent studies have implicated MDMA metabolites, but their precise role remains unclear. To further evaluate the relative importance of metabolites versus the parent compound in neurotoxicity, we explored the relationship between pharmacok...
متن کاملFurther Studies on the Role of Metabolites in MDMA-induced Serotonergic Neurotoxicity
Department of Neurology (MM, JY, GR) and Psychiatry and Behavioral Sciences (UM), Johns Hopkins University School of Medicine, Baltimore, MD 21224; UMR 8638 associée au CNRS (AF, AN, ML), Université Paris Descartes, 75270 Paris cedex 06, France; Department of Experimental and Clinical Toxicology (MM, FP, HM), Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland Universit...
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The popular recreational drug, (+/-)3, 4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a potent and selective brain serotonin (5-HT) neurotoxin in animals. MDMA-induced 5-HT neurotoxicity can be demonstrated using a variety of neurochemical, neuroanatomical and, more recently, functional measures of 5-HT neurons. Although the neurotoxic effects of MDMA in animals are widely accepted, the r...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2009
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.109.028340